October 7, 2021 (Investorideas.com Newswire) Shares of Voyager Therapeutics Inc. traded 51% larger after the corporate reported it entered right into a license and choice settlement with Pfizer Inc. for 2 of its TRACER AAV capsids that might be utilized to boost Pfizer’s neurologic and cardiovascular gene remedy packages. Voyager will obtain an upfront cost of $30 million and is eligible to obtain as much as $600 million extra plus product sales-based royalties, if all choices are exercised and sure milestones are achieved.
Medical-stage gene remedy firm Voyager Therapeutics Inc. (VYGR:NASDAQ), which is targeted on the event of therapies for central nervous system (CNS) illnesses and next-generation adeno-associated virus (AAV) platform applied sciences, right now announced “an settlement via which Pfizer Inc. (PFE:NYSE) could train choices to license novel capsids generated from Voyager’s RNA-driven TRACER™ (Tropism Redirection of AAV by Cell-type-specific Expression of RNA) screening know-how as a part of Pfizer’s efforts to develop, manufacture, and commercialize gene therapies, using two undisclosed transgenes to deal with sure neurologic and cardiovascular illnesses.”
Voyager Therapeutics’ Interim CEO Michael Higgins commented, “This transaction highlights the potential of our TRACER platform to establish novel AAV capsids that concentrate on desired cells and tissues with higher specificity at decrease doses and with fewer off-target dangers than typical AAV serotypes…We consider that our TRACER platform has the flexibility to provide not solely enhanced blood-brain-barrier penetrant capsids, but in addition novel capsids with enhanced tropisms throughout a variety of tissues and cell sorts, providing promise to unlock the fullest potential of gene therapies for a wide selection of illnesses with unmet medical want.”
Seng Cheng, Ph.D., SVP and Chief Scientific Officer of Pfizer’s Uncommon Illness Analysis Unit remarked, “Our collaboration with Voyager will present Pfizer with entry to extra AAV capsids which will assist additional advance our industry-leading gene remedy portfolio…We’re impressed with Voyager’s outcomes to this point and are enthusiastic concerning the potential to make the most of these novel capsids to assist speed up the event of latest therapeutic choices for sufferers dwelling with sure neurologic and cardiovascular illnesses.”
Voyager claimed that “proprietary AAV capsids derived from Voyager’s TRACER platform have demonstrated superior blood-brain-barrier penetration, enhanced cardiac muscle tropism, and elevated transgene expression in goal tissues in comparison with typical AAV capsids as measured in non-human primates (NHPs).”
Execution of the settlement gives Pfizer with the rights to pick out and consider novel capsids for CNS and cardiac tropisms from Voyager’s TRACER platform. As well as, Pfizer will have the ability to train choices to completely license these capsids for its AAV gene therapies growth efforts that incorporate two particular undisclosed transgenes.
Underneath the phrases of the settlement, Voyager will retain the complete world rights to all different licensed capsids to be used with different transgenes in its growth pipeline in addition to all different purposes of its TRACER know-how.
The settlement stipulates that Pfizer is to pay Voyager $30 million upfront and an extra $20 million in train charges for 2 choices, ought to Pfizer elect to train these choices that are legitimate for a interval of 12 months from signing. The report indicated that, “Voyager can even be eligible to earn as much as $580 million in whole growth, regulatory and business milestones related to licensed merchandise incorporating the 2 undisclosed Pfizer transgenes along with a Voyager licensed capsid.” On high of the develop and milestone funds, the agency could also be entitled to obtain mid- to high-single-digit tiered royalties from web gross sales of Pfizer’s merchandise that include the licensed capsids.
The corporate defined that its TRACERᵀᴹ AAV capsid discovery system is “a broadly relevant, RNA-based practical screening platform that enables for fast in vivo evolution of AAV capsids with enhanced tropisms and cell- and tissue-specific transduction properties in a number of species, together with non-human primates (NHPs).”
Voyager Therapeutics relies in Cambridge, Mass., and is actively engaged within the growth of subsequent technology adeno-associated virus (AAV) gene therapies to deal with devastating illnesses. The corporate acknowledged that, “proprietary capsids born from its TRACER screening platform are powering a wealthy early-stage pipeline of latest and second-generation packages and should elevate the sphere to beat the restrictions of typical gene remedy vectors throughout neurologic issues and different therapeutic areas.” The agency at current is essentially targeted on a number of extreme neurological illnesses together with Huntington’s illness, spinal muscular atrophy and SOD1, which is a monogenic type of amyotrophic lateral sclerosis.
Pfizer is headquartered in New York, N.Y., and is a research-based world biopharma firm concerned in discovery, growth and manufacturing of prescription drugs and different numerous healthcare merchandise. The agency’s world portfolio contains dozens of brand name prescription medicines together with Celebrex, Eliquis, Lipitor, Prevnar 13, Pristiq, Viagra, and Xeljanz. Pfizer has a market cap exceeding $237 billion.
Voyager Therapeutics started the day with a market cap of round $93.7 million with roughly 37.94 million shares excellent and a brief curiosity of about 2.3%. VYGR shares opened greater than 60% larger right now at $3.99 (+$1.52, +61.54%) over yesterday’s $2.47 closing value. The inventory has traded right now between $3.49 and $4.12 per share and is at the moment buying and selling at $3.74 (+$1.27, +51.42%).
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